Occupational stress is a pervasive issue in the nursing profession due to high workload, emotional labor, long working hours, and responsibility for patient outcomes. Persistent exposure to stressful work environments can negatively influence nurses’ job satisfaction, mental well-being, and quality of patient care. This study examines the relationship between occupational stress and job satisfaction among staff nurses working in tertiary care hospitals. A quantitative descriptive correlational research design was employed, and data were collected from 220 staff nurses using standardized occupational stress and job satisfaction scales. Statistical analysis revealed a significant negative correlation between occupational stress and job satisfaction. Factors such as workload, shift duties, inadequate staffing, and lack of managerial support emerged as major stressors. The findings highlight the urgent need for organizational interventions to reduce stress and enhance job satisfaction among nurses. Improving work conditions and providing psychological support can contribute to nurse retention, improved performance, and better patient outcomes.